Human GALNTL2 (GALNT15) activation kit by CRISPRa

CAT#: GA114641

GALNT15 CRISPRa kit - CRISPR gene activation of human polypeptide N-acetylgalactosaminyltransferase 15

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GALNT15
• Locus ID: 117248
• Kit Components:

  GA114641G1, GALNT15 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114641G2, GALNT15 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114641G3, GALNT15 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319051, NM_001319052, NM_054110
• Synonyms: GALNACT15; GALNT7; GALNT13; GALNTL2; PIH5; pp-GalNAc-T15
• Summary: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate. [UniProtKB/Swiss-Prot Function]