Human EXOSC6 activation kit by CRISPRa

CAT#: GA114660

EXOSC6 CRISPRa kit - CRISPR gene activation of human exosome component 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: EXOSC6
• Locus ID: 118460
• Kit Components:

  GA114660G1, EXOSC6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114660G2, EXOSC6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114660G3, EXOSC6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_058219
• Synonyms: EAP4; hMtr3p; MTR3; Mtr3p; p11
• Summary: This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]