Human Calreticulin 3 (CALR3) activation kit by CRISPRa

CAT#: GA114903

CALR3 CRISPRa kit - CRISPR gene activation of human calreticulin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CALR3
• Locus ID: 125972
• Kit Components:

  GA114903G1, CALR3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA114903G2, CALR3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA114903G3, CALR3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_145046
• Synonyms: CMH19; CRT2; CT93
• Summary: The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]