Human VPS37A activation kit by CRISPRa

CAT#: GA115282

VPS37A CRISPRa kit - CRISPR gene activation of human VPS37A subunit of ESCRT-I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VPS37A
• Locus ID: 137492
• Kit Components:

  GA115282G1, VPS37A gRNA vector 1 in pCas-Guide-CRISPRa

  GA115282G2, VPS37A gRNA vector 2 in pCas-Guide-CRISPRa

  GA115282G3, VPS37A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145152, NM_152415, NM_001363167, NM_001363168, NM_001363171, NM_001363172, NM_001363173, NM_001363169, NM_001363170
• Synonyms: HCRP1; PQBP2; SPG53
• Summary: This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]