Human A2ML1 activation kit by CRISPRa

CAT#: GA115502

A2ML1 CRISPRa kit - CRISPR gene activation of human alpha-2-macroglobulin like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: A2ML1
• Locus ID: 144568
• Kit Components:

  GA115502G1, A2ML1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115502G2, A2ML1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115502G3, A2ML1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282424, NM_144670, NR_046256
• Synonyms: CPAMD9
• Summary: This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]