Human AGR3 activation kit by CRISPRa

CAT#: GA115916

AGR3 CRISPRa kit - CRISPR gene activation of human anterior gradient 3, protein disulphide isomerase family member

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AGR3
• Locus ID: 155465
• Kit Components:

  GA115916G1, AGR3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA115916G2, AGR3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA115916G3, AGR3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_176813
• Synonyms: AG-3; AG3; BCMP11; hAG-3; HAG3; PDIA18
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]