Human NAGS activation kit by CRISPRa

CAT#: GA116046

NAGS CRISPRa kit - CRISPR gene activation of human N-acetylglutamate synthase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NAGS
• Locus ID: 162417
• Kit Components:

  GA116046G1, NAGS gRNA vector 1 in pCas-Guide-CRISPRa

  GA116046G2, NAGS gRNA vector 2 in pCas-Guide-CRISPRa

  GA116046G3, NAGS gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_153006
• Synonyms: AGAS; ARGA
• Summary: The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]