Human TOR1AIP2 activation kit by CRISPRa

CAT#: GA116092

TOR1AIP2 CRISPRa kit - CRISPR gene activation of human torsin 1A interacting protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TOR1AIP2
• Locus ID: 163590
• Kit Components:

  GA116092G1, TOR1AIP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA116092G2, TOR1AIP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA116092G3, TOR1AIP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199260, NM_022347, NM_145034, NM_001349931, NM_001349933, NM_001349934, NM_001349935, NM_001349936, NM_001349937
• Synonyms: IFRG15; LULL1; NET9
• Summary: One of the two protein isoforms encoded by this gene is a type II integral membrane protein found in the endoplasmic reticulum (ER). The encoded protein is a cofactor for the ATPase TorsinA, regulating the amount of TorsinA present in the ER compared to that found in the nuclear envelope. Defects in this protein are a cause of early onset primary dystonia, a neuromuscular disease. The other isoform encoded by this gene is an interferon alpha responsive protein whose cellular role has yet to be determined. [provided by RefSeq, Mar 2017]