Human SVIP activation kit by CRISPRa

CAT#: GA116902

SVIP CRISPRa kit - CRISPR gene activation of human small VCP interacting protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SVIP
• Locus ID: 258010
• Kit Components:

  GA116902G1, SVIP gRNA vector 1 in pCas-Guide-CRISPRa

  GA116902G2, SVIP gRNA vector 2 in pCas-Guide-CRISPRa

  GA116902G3, SVIP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_148893, NM_001320340, NM_001320341, NM_001320342, NR_135213
• Synonyms: DKFZp313A2432
• Summary: Endoplasmic reticulum-associated degradation (ERAD) is the pathway by which misfolded proteins in the endoplasmic reticulum are targeted to the proteasome for degradation. Multiple specialized proteins interact with one another during ERAD to complete this process. The protein encoded by this gene is an inhibitor of ERAD, functioning to disrupt the interaction of these protein components. This downregulation of ERAD may be needed to protect the cell from overactive protein degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]