Human DAOA activation kit by CRISPRa

CAT#: GA116956

DAOA CRISPRa kit - CRISPR gene activation of human D-amino acid oxidase activator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DAOA
• Locus ID: 267012
• Kit Components:

  GA116956G1, DAOA gRNA vector 1 in pCas-Guide-CRISPRa

  GA116956G2, DAOA gRNA vector 2 in pCas-Guide-CRISPRa

  GA116956G3, DAOA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161812, NM_001161814, NM_172370
• Synonyms: LG72; SG72
• Summary: This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Mar 2011]