Human KCTD1 activation kit by CRISPRa

CAT#: GA117108

KCTD1 CRISPRa kit - CRISPR gene activation of human potassium channel tetramerization domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCTD1
• Locus ID: 284252
• Kit Components:

  GA117108G1, KCTD1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117108G2, KCTD1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117108G3, KCTD1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136205, NM_001142730, NM_001258221, NM_001258222, NM_198991, NM_001351443
• Synonyms: C18orf5; SENS
• Summary: This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]