Human FBXO43 activation kit by CRISPRa

CAT#: GA117280

FBXO43 CRISPRa kit - CRISPR gene activation of human F-box protein 43

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FBXO43
• Locus ID: 286151
• Kit Components:

  GA117280G1, FBXO43 gRNA vector 1 in pCas-Guide-CRISPRa

  GA117280G2, FBXO43 gRNA vector 2 in pCas-Guide-CRISPRa

  GA117280G3, FBXO43 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001029860, NM_001077528, NR_036491
• Synonyms: EMI2; ERP1; FBX43
• Summary: Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Mar 2008]