Human MMAB activation kit by CRISPRa

CAT#: GA117332

MMAB CRISPRa kit - CRISPR gene activation of human metabolism of cobalamin associated B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MMAB
• Locus ID: 326625
• Kit Components:

  GA117332G1, MMAB gRNA vector 1 in pCas-Guide-CRISPRa

  GA117332G2, MMAB gRNA vector 2 in pCas-Guide-CRISPRa

  GA117332G3, MMAB gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_052845, NR_038118
• Synonyms: ATR; cblB; CFAP23; cob
• Summary: This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]