Human IRGM activation kit by CRISPRa

CAT#: GA117613

IRGM CRISPRa kit - CRISPR gene activation of human immunity related GTPase M

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRGM
• Locus ID: 345611
• Kit Components:

  GA117613G1, IRGM gRNA vector 1 in pCas-Guide-CRISPRa

  GA117613G2, IRGM gRNA vector 2 in pCas-Guide-CRISPRa

  GA117613G3, IRGM gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145805, NM_001346557
• Synonyms: IFI1; IRGM1; LRG-47; LRG47
• Summary: This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]