Human DEFB104B activation kit by CRISPRa

CAT#: GA118601

DEFB104B CRISPRa kit - CRISPR gene activation of human defensin beta 104B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DEFB104B
• Locus ID: 503618
• Kit Components:

  GA118601G1, DEFB104B gRNA vector 1 in pCas-Guide-CRISPRa

  GA118601G2, DEFB104B gRNA vector 2 in pCas-Guide-CRISPRa

  GA118601G3, DEFB104B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040702
• Synonyms: BD-4; DEFB-4; hBD-4
• Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]