Human DEFB105B activation kit by CRISPRa

CAT#: GA118605

DEFB105B CRISPRa kit - CRISPR gene activation of human defensin beta 105B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DEFB105B
• Locus ID: 504180
• Kit Components:

  GA118605G1, DEFB105B gRNA vector 1 in pCas-Guide-CRISPRa

  GA118605G2, DEFB105B gRNA vector 2 in pCas-Guide-CRISPRa

  GA118605G3, DEFB105B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001040703
• Synonyms: BD-5; DEFB-5
• Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]