Human ECSCR activation kit by CRISPRa

CAT#: GA118659

ECSCR CRISPRa kit - CRISPR gene activation of human endothelial cell surface expressed chemotaxis and apoptosis regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ECSCR
• Locus ID: 641700
• Kit Components:

  GA118659G1, ECSCR gRNA vector 1 in pCas-Guide-CRISPRa

  GA118659G2, ECSCR gRNA vector 2 in pCas-Guide-CRISPRa

  GA118659G3, ECSCR gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077693, NM_001293739, NR_121659
• Synonyms: ARIA; ECSM2
• Summary: The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]