Human D2HGDH activation kit by CRISPRa

CAT#: GA118924

D2HGDH CRISPRa kit - CRISPR gene activation of human D-2-hydroxyglutarate dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: D2HGDH
• Locus ID: 728294
• Kit Components:

  GA118924G1, D2HGDH gRNA vector 1 in pCas-Guide-CRISPRa

  GA118924G2, D2HGDH gRNA vector 2 in pCas-Guide-CRISPRa

  GA118924G3, D2HGDH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001287249, NM_152783, NR_109778, NM_001352824
• Synonyms: D2HGD
• Summary: This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]