Mouse Acadl activation kit by CRISPRa

CAT#: GA200013

Acadl CRISPRa kit - CRISPR gene activation of mouse acyl-Coenzyme A dehydrogenase, long-chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Acadl
• Locus ID: 11363
• Kit Components:

  GA200013G1, Acadl gRNA vector 1 in pCas-Guide-CRISPRa

  GA200013G2, Acadl gRNA vector 2 in pCas-Guide-CRISPRa

  GA200013G3, Acadl gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007381
• Synonyms: AA960361; AU018452; C79855; LCAD
• Summary: This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]