Mouse Aspa activation kit by CRISPRa

CAT#: GA200057

Aspa CRISPRa kit - CRISPR gene activation of mouse aspartoacylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Aspa
• Locus ID: 11484
• Kit Components:

  GA200057G1, Aspa gRNA vector 1 in pCas-Guide-CRISPRa

  GA200057G2, Aspa gRNA vector 2 in pCas-Guide-CRISPRa

  GA200057G3, Aspa gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_023113
• Synonyms: Acy-2; Acy2; nur7
• Summary: This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012]