Mouse Adnp activation kit by CRISPRa

CAT#: GA200090

Adnp CRISPRa kit - CRISPR gene activation of mouse activity-dependent neuroprotective protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Adnp
• Locus ID: 11538
• Kit Components:

  GA200090G1, Adnp gRNA vector 1 in pCas-Guide-CRISPRa

  GA200090G2, Adnp gRNA vector 2 in pCas-Guide-CRISPRa

  GA200090G3, Adnp gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001310086, NM_001310088, NM_009628
• Synonyms: AA589558; mKIAA0784
• Summary: This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]