Mouse Aga activation kit by CRISPRa

CAT#: GA200116

Aga CRISPRa kit - CRISPR gene activation of mouse aspartylglucosaminidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Aga
• Locus ID: 11593
• Kit Components:

  GA200116G1, Aga gRNA vector 1 in pCas-Guide-CRISPRa

  GA200116G2, Aga gRNA vector 2 in pCas-Guide-CRISPRa

  GA200116G3, Aga gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005847, NM_001205054
• Synonyms: AW060726
• Summary: This gene encodes an amidase enzyme that participates in the breakdown of glycoproteins in the cell. The encoded protein undergoes proteolytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit accumulation of aspartylglucosamine along with lysosomal vacuolization, axonal swelling in the gracile nucleus and impaired neuromotor coordination. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]