Mouse Ahr activation kit by CRISPRa

CAT#: GA200133

Ahr CRISPRa kit - CRISPR gene activation of mouse aryl-hydrocarbon receptor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ahr
• Locus ID: 11622
• Kit Components:

  GA200133G1, Ahr gRNA vector 1 in pCas-Guide-CRISPRa

  GA200133G2, Ahr gRNA vector 2 in pCas-Guide-CRISPRa

  GA200133G3, Ahr gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001314027, NM_013464
• Synonyms: Ah; Ahh; Ahre; bHLHe76; In
• Summary: The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]