Mouse Ambp activation kit by CRISPRa

CAT#: GA200176

Ambp CRISPRa kit - CRISPR gene activation of mouse alpha 1 microglobulin/bikunin precursor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ambp
• Locus ID: 11699
• Kit Components:

  GA200176G1, Ambp gRNA vector 1 in pCas-Guide-CRISPRa

  GA200176G2, Ambp gRNA vector 2 in pCas-Guide-CRISPRa

  GA200176G3, Ambp gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007443
• Synonyms: AI194774; ASPI; HI-30; Intin4; Itil; UTI
• Summary: This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis. [provided by RefSeq, Oct 2015]