Mouse Birc5 activation kit by CRISPRa

CAT#: GA200231

Birc5 CRISPRa kit - CRISPR gene activation of mouse baculoviral IAP repeat-containing 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Birc5
• Locus ID: 11799
• Kit Components:

  GA200231G1, Birc5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200231G2, Birc5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200231G3, Birc5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001012273, NM_009689, NM_001012272
• Synonyms: AAC-11; Api4; survivin40; TIAP
• Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]