Mouse Cdkn1c activation kit by CRISPRa

CAT#: GA200678

Cdkn1c CRISPRa kit - CRISPR gene activation of mouse cyclin-dependent kinase inhibitor 1C (P57)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cdkn1c
• Locus ID: 12577
• Kit Components:

  GA200678G1, Cdkn1c gRNA vector 1 in pCas-Guide-CRISPRa

  GA200678G2, Cdkn1c gRNA vector 2 in pCas-Guide-CRISPRa

  GA200678G3, Cdkn1c gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001161624, NM_009876, NM_001354981
• Synonyms: AL024410; CDKI; Kip2; p57(kip2); p57Kip2
• Summary: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProtKB/Swiss-Prot Function]