Mouse Col4a2 activation kit by CRISPRa

CAT#: GA200815

Col4a2 CRISPRa kit - CRISPR gene activation of mouse collagen, type IV, alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Col4a2
• Locus ID: 12827
• Kit Components:

  GA200815G1, Col4a2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200815G2, Col4a2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200815G3, Col4a2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_009932
• Synonyms: Col4a-2
• Summary: This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV collagen network. Canstatin, a peptide derived fom the C-terminus of the collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Nov 2015]