Mouse Col5a2 activation kit by CRISPRa

CAT#: GA200820

Col5a2 CRISPRa kit - CRISPR gene activation of mouse collagen, type V, alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Col5a2
• Locus ID: 12832
• Kit Components:

  GA200820G1, Col5a2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200820G2, Col5a2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200820G3, Col5a2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007737
• Synonyms: 1110014L14Rik
• Summary: This gene encodes the alpha-2 subunit of type V collagen, one of the low abundance fibrillar collagens that gets incorporated into growing fibrils with type I collagen. The encoded protein, in association with alpha-1 and/or alpha-3 subunits, forms homo- or heterotrimeric type V procollagen that undergoes proteolytic processing. Mice lacking the encoded protein die in utero. Transgenic mice that produce a structurally abnormal form of the encoded protein survive poorly and exhibit skin fragility, skeletal abnormalities and alterations in the collagen fiber organization. [provided by RefSeq, Dec 2015]