Mouse Col1a2 activation kit by CRISPRa

CAT#: GA200830

Col1a2 CRISPRa kit - CRISPR gene activation of mouse collagen, type I, alpha 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Col1a2
• Locus ID: 12843
• Kit Components:

  GA200830G1, Col1a2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200830G2, Col1a2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200830G3, Col1a2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007743
• Synonyms: AA960264; AI325291; Col1a-2; Cola-2; Cola2; oim
• Summary: This gene encodes the alpha-2 subunit of the fibril-forming type I collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-1 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice harboring certain mutations in the encoded gene exhibit symptoms of moderate to severe forms of osteogenesis imperfecta. [provided by RefSeq, Dec 2015]