Mouse Cpe activation kit by CRISPRa

CAT#: GA200852

Cpe CRISPRa kit - CRISPR gene activation of mouse carboxypeptidase E

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Cpe
• Locus ID: 12876
• Kit Components:

  GA200852G1, Cpe gRNA vector 1 in pCas-Guide-CRISPRa

  GA200852G2, Cpe gRNA vector 2 in pCas-Guide-CRISPRa

  GA200852G3, Cpe gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013494
• Synonyms: CPH; Cph-1; Cph1; fat; NF-alpha1; R74677
• Summary: This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]