Mouse Crhr2 activation kit by CRISPRa

CAT#: GA200874

Crhr2 CRISPRa kit - CRISPR gene activation of mouse corticotropin releasing hormone receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Crhr2
• Locus ID: 12922
• Kit Components:

  GA200874G1, Crhr2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA200874G2, Crhr2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA200874G3, Crhr2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001288618, NM_001288619, NM_001288620, NM_009953
• Synonyms: CRF-R2; Crfr2; CRFR2alpha; CRFR2beta
• Summary: G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. [UniProtKB/Swiss-Prot Function]