Mouse S1pr1 activation kit by CRISPRa

CAT#: GA201174

S1pr1 CRISPRa kit - CRISPR gene activation of mouse sphingosine-1-phosphate receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: S1pr1
• Locus ID: 13609
• Kit Components:

  GA201174G1, S1pr1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201174G2, S1pr1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201174G3, S1pr1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007901
• Synonyms: AI849002; Edg1; Lpb1; S1p; S1p1
• Summary: This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]