Mouse Edn2 activation kit by CRISPRa

CAT#: GA201179

Edn2 CRISPRa kit - CRISPR gene activation of mouse endothelin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Edn2
• Locus ID: 13615
• Kit Components:

  GA201179G1, Edn2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201179G2, Edn2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201179G3, Edn2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007902
• Synonyms: ET-2; PPET2; VIC
• Summary: This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a potent vasoconstrictive peptide. This gene is abundantly expressed in the gastrointestinal tract, strongly induced in photorecepteror cells in retinal diseases and injury, and produced by microglia and macrophages in the early stages of glaucoma. Mice lacking the encoded protein exhibit severe growth retardation, hypothermia and juvenile lethality. [provided by RefSeq, Feb 2016]