Mouse F7 activation kit by CRISPRa

CAT#: GA201341

F7 CRISPRa kit - CRISPR gene activation of mouse coagulation factor VII

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: F7
• Locus ID: 14068
• Kit Components:

  GA201341G1, F7 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201341G2, F7 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201341G3, F7 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010172
• Synonyms: AI132620; Cf7; FVII
• Summary: This gene encodes a vitamin K-dependent serine protease that plays a critical role in the extrinsic pathway of blood coagulation. Upon contact with tissue factor III (TF III), the encoded protein forms an activated complex termed TF-FVIIa that initiates the coagulation cascade involving other coagulation factors, ultimately resulting in a fibrin clot. Complete lack of the encoded protein in mice results in in perinatal lethality due to bleeding from normal blood vessels. [provided by RefSeq, Apr 2015]