Mouse Fgd1 activation kit by CRISPRa

CAT#: GA201390

Fgd1 CRISPRa kit - CRISPR gene activation of mouse FYVE, RhoGEF and PH domain containing 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Fgd1
• Locus ID: 14163
• Kit Components:

  GA201390G1, Fgd1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201390G2, Fgd1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201390G3, Fgd1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008001
• Synonyms: ZFYVE3
• Summary: This gene encodes a member of family of Rho-specific guanine nucleotide exchange factors. Rho-specific guanine nucleotide exchange factors catalyze the exchange of GDP for GTP and activate small GTPases, which function as molecular switches in signaling. This protein specifically binds cell division cycle 42, a Rho (Ras homology) GTPase. Investigations in mouse suggest that this protein is important for skeletal mineralization and for regulating the actin cytoskeleton. In humans, mutations in this gene are associated with faciogenital dysplasia, also known as Aarskog-Scott syndrome. [provided by RefSeq, Mar 2014]