Mouse Galc activation kit by CRISPRa

CAT#: GA201532

Galc CRISPRa kit - CRISPR gene activation of mouse galactosylceramidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Galc
• Locus ID: 14420
• Kit Components:

  GA201532G1, Galc gRNA vector 1 in pCas-Guide-CRISPRa

  GA201532G2, Galc gRNA vector 2 in pCas-Guide-CRISPRa

  GA201532G3, Galc gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008079
• Synonyms: 2310068B06Rik; A930008M05Rik; AW212969; AW413532; Gacy; twi; twitcher
• Summary: This gene encodes galactosylceramidase, the lysosomal hydryolase involved in the catabolism of galactosylceramide. Mutations in this gene result in slow growth, tremors and hind leg weakness, collectively termed as the 'twitcher' phenotype. In humans, deficiency of this gene product causes a lysosomal storage disorder known as Krabbe disease. [provided by RefSeq, Dec 2014]