Mouse Gria2 activation kit by CRISPRa

CAT#: GA201732

Gria2 CRISPRa kit - CRISPR gene activation of mouse glutamate receptor, ionotropic, AMPA2 (alpha 2)

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gria2
• Locus ID: 14800
• Kit Components:

  GA201732G1, Gria2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201732G2, Gria2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201732G3, Gria2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039195, NM_001083806, NM_013540, NM_001357924, NM_001357927, NR_152147, NR_152148, NR_152149
• Synonyms: GluA2; Glur-2; GluR-B; Glur2
• Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]