Mouse Grm1 activation kit by CRISPRa

CAT#: GA201746

Grm1 CRISPRa kit - CRISPR gene activation of mouse glutamate receptor, metabotropic 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Grm1
• Locus ID: 14816
• Kit Components:

  GA201746G1, Grm1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA201746G2, Grm1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA201746G3, Grm1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001114333, NM_016976
• Synonyms: 4930455H15Rik; ENSMUSG00000075319; Gm10828; Gprc1a; mGluR1; nmf373; rcw; wobl
• Summary: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). [UniProtKB/Swiss-Prot Function]