Mouse Gzmb activation kit by CRISPRa

CAT#: GA201793

Gzmb CRISPRa kit - CRISPR gene activation of mouse granzyme B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Gzmb
• Locus ID: 14939
• Kit Components:

  GA201793G1, Gzmb gRNA vector 1 in pCas-Guide-CRISPRa

  GA201793G2, Gzmb gRNA vector 2 in pCas-Guide-CRISPRa

  GA201793G3, Gzmb gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013542
• Synonyms: AI553453; CCP-1/C11; CCP1; Ctla-1; Ctla1; GZB
• Summary: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Mice lacking a functional copy of this gene exhibit impaired immune cell-mediated cytolysis. [provided by RefSeq, Sep 2016]