Mouse Il17a activation kit by CRISPRa

CAT#: GA202128

Il17a CRISPRa kit - CRISPR gene activation of mouse interleukin 17A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Il17a
• Locus ID: 16171
• Kit Components:

  GA202128G1, Il17a gRNA vector 1 in pCas-Guide-CRISPRa

  GA202128G2, Il17a gRNA vector 2 in pCas-Guide-CRISPRa

  GA202128G3, Il17a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010552
• Synonyms: Ctla-8; Ctla8; IL-17; IL-17A; Il17
• Summary: This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]