Mouse Ins1 activation kit by CRISPRa

CAT#: GA202174

Ins1 CRISPRa kit - CRISPR gene activation of mouse insulin I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Ins1
• Locus ID: 16333
• Kit Components:

  GA202174G1, Ins1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202174G2, Ins1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202174G3, Ins1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008386
• Synonyms: Ins-1; Ins2-rs1
• Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. [provided by RefSeq, Aug 2015]