Mouse Mgp activation kit by CRISPRa

CAT#: GA202653

Mgp CRISPRa kit - CRISPR gene activation of mouse matrix Gla protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mgp
• Locus ID: 17313
• Kit Components:

  GA202653G1, Mgp gRNA vector 1 in pCas-Guide-CRISPRa

  GA202653G2, Mgp gRNA vector 2 in pCas-Guide-CRISPRa

  GA202653G3, Mgp gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008597
• Synonyms: Mglap
• Summary: This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. This protein also inhibits angiogenesis. Mice lacking a functional copy of this gene exhibit impaired differentiation of endothelial cells, reduced stature, and calcification and rupture of the vasculature leading to premature death. [provided by RefSeq, Sep 2016]