Mouse Mmp13 activation kit by CRISPRa

CAT#: GA202677

Mmp13 CRISPRa kit - CRISPR gene activation of mouse matrix metallopeptidase 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Mmp13
• Locus ID: 17386
• Kit Components:

  GA202677G1, Mmp13 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202677G2, Mmp13 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202677G3, Mmp13 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008607
• Synonyms: Clg; MMP-13; Mmp1
• Summary: This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]