Mouse Meis2 activation kit by CRISPRa

CAT#: GA202714

Meis2 CRISPRa kit - CRISPR gene activation of mouse Meis homeobox 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Meis2
• Locus ID: 17536
• Kit Components:

  GA202714G1, Meis2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202714G2, Meis2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202714G3, Meis2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001136072, NM_001159567, NM_001159568, NM_001159569, NM_001159570, NM_001346036, NM_001346038, NM_001346041, NM_001346044, NM_001346045, NM_001346047, NM_001346053, NM_001346055, NM_001346056, NM_010825
• Synonyms: A430109D20Rik; Mrg1; Stra10
• Summary: This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcriptional regulators and several members have been shown to be essential contributors to developmental programs. In mice, a knock-out of this gene leads to lethality at embryonic day 14, accompanied with hemorrhaging. Embryos lacking this gene show defects in tissues derived from the neural crest, suggesting a critical role of this gene during cranial and cardiac neural crest cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]