Mouse Nr4a3 activation kit by CRISPRa

CAT#: GA202932

Nr4a3 CRISPRa kit - CRISPR gene activation of mouse nuclear receptor subfamily 4, group A, member 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Nr4a3
• Locus ID: 18124
• Kit Components:

  GA202932G1, Nr4a3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202932G2, Nr4a3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202932G3, Nr4a3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001307989, NM_015743
• Synonyms: AI573420; CHN; CSMF; MINOR; NOR-1; Nor1; TEC
• Summary: This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]