Mouse Slc11a1 activation kit by CRISPRa

CAT#: GA202961

Slc11a1 CRISPRa kit - CRISPR gene activation of mouse solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Slc11a1
• Locus ID: 18173
• Kit Components:

  GA202961G1, Slc11a1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA202961G2, Slc11a1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA202961G3, Slc11a1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013612
• Synonyms: Bcg; Ity; ity; Ity1; Lsh; Nramp; Nramp1
• Summary: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. [UniProtKB/Swiss-Prot Function]