Mouse Oprk1 activation kit by CRISPRa

CAT#: GA203050

Oprk1 CRISPRa kit - CRISPR gene activation of mouse opioid receptor, kappa 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Oprk1
• Locus ID: 18387
• Kit Components:

  GA203050G1, Oprk1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203050G2, Oprk1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203050G3, Oprk1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001204371, NM_001318735, NM_011011
• Synonyms: K-OR-1; KOR; KOR-1; MSL-1; Oprk2; R21
• Summary: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]