Mouse Pea15a activation kit by CRISPRa

CAT#: GA203168

Pea15a CRISPRa kit - CRISPR gene activation of mouse phosphoprotein enriched in astrocytes 15A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Pea15a
• Locus ID: 18611
• Kit Components:

  GA203168G1, Pea15a gRNA vector 1 in pCas-Guide-CRISPRa

  GA203168G2, Pea15a gRNA vector 2 in pCas-Guide-CRISPRa

  GA203168G3, Pea15a gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001329869, NM_001329871, NM_011063
• Synonyms: Mat1; PEA-15; Pea15; Pkcs15
• Summary: This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]