Mouse Plpp1 activation kit by CRISPRa

CAT#: GA203337

Plpp1 CRISPRa kit - CRISPR gene activation of mouse phospholipid phosphatase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Plpp1
• Locus ID: 19012
• Kit Components:

  GA203337G1, Plpp1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA203337G2, Plpp1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA203337G3, Plpp1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_008247, NM_008903
• Synonyms: Hic53; Hpic53; LPP-1; LPP1; mPAP; PAP-2a; PAP2-alpha; PAP2a; Ppap2a
• Summary: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P. [UniProtKB/Swiss-Prot Function]