Mouse Stat4 activation kit by CRISPRa

CAT#: GA204125

Stat4 CRISPRa kit - CRISPR gene activation of mouse signal transducer and activator of transcription 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: Stat4
• Locus ID: 20849
• Kit Components:

  GA204125G1, Stat4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA204125G2, Stat4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA204125G3, Stat4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308266, NM_011487
• Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]